@conference {91, title = {Dependable computing in virtual laboratories}, booktitle = {17th IEEE International Conference on Data Engineering (ICDE 2001)}, year = {2001}, month = {April}, pages = {235 - 242}, publisher = {IEEE}, organization = {IEEE}, address = {Heidelberg, Germany}, abstract = {Many scientific disciplines are shifting from in vitro to in silico research as more physical processes and natural phenomena are examined in a computer (in silico) instead of being observed (in vitro). In many of these virtual laboratories, the computations involved are very complex and long lived. Currently, users are required to manually handle almost all aspects of such computations, including their dependability. Not surprisingly, this is a major bottleneck and a significant source of inefficiencies. To address this issue, we have developed BioOpera, an extensible process support management system for virtual laboratories. The authors briefly discuss the architecture and functionality of BioOpera and show how it can be used to efficiently manage long lived computations}, keywords = {bioinformatics, BioOpera, scientific workflow management, virtual laboratories}, doi = {10.1109/ICDE.2001.914834}, url = {http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=914834}, author = {Gustavo Alonso and Win Bausch and Cesare Pautasso and Ari Kahn} }